Hi,
I am looking for a full-card SIM programmer to use with pySim and GR-Card SIMs.
I'd recommend any reader that is USB CCID compliant (so you don't need vendor specific drivers).
http://pcsclite.alioth.debian.org/ccid/supported.html
I hqve a gemalto pc twin reader personally. I use it under linux all the time (both with pcsc and other application). I also used it on mac osx but I never tried py-sim there.
Cheers,
Sylvain