Neels,
A reason could be that osmo-trx is losing connection with the SDR. Are you running this on bare metal or a VM?
USB based SDRs like USRP B2x0 have hard time keeping the Tx/Rx alignment when there are any disturbances. So osmo-trx features a sophisticated algorithm to maintain this alignment for USB based devices. Thomas has spent tremendous effort tuning it to perform well, but may be there are edge cases which are not handled there yet. Let's wait for his comments.
(That's one the primary reasons we use Ethernet in UmTRX, btw - it's much more robust to issues like this)
Please excuse typos. Written with a touchscreen keyboard.
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Regards,
Alexander Chemeris
CTO/Founder Fairwaves, Inc.
https://fairwaves.co